
Your mind in 20 years is being shaped right now.
From your mid-forties, names take a second longer. Focus slips. Thoughts come a beat slower than they used to.That's normal cognitive ageing and it's been happening for years. But the way the mind ages can be shaped by what we do.
Cognitive change starts earlier than most people think.
Cognitive change starts earlier than most people think.
Midlife is the time to act.
Constance is one place to start.
Founded by Sarah, Cambridge PhD in chemistry
Midlife is the time to act.
Constance is one place to start.
Founded by Sarah, Cambridge PhD in chemistry
A daily habit for your mind. And the hope of lifelong mind-span.
Mind-span is how long the mind stays sharp as the years add up.
That means thinking quickly, finding the word in the moment, holding a train of thought. A mind that still feels like yours.
Constance is a daily capsule and an evening ritual, informed by the science.
A daily habit for your mind. And the hope of lifelong mind-span.
Mind-span is how long the mind stays sharp as the years add up.
That means thinking quickly, finding the word in the moment, holding a train of thought. A mind that still feels like yours.
Constance is a daily capsule and an evening ritual, informed by the science.


Mind Capsules
Omega-3 DHA from algal oil and MemophenolTM, wild blueberry and whole grape extracts. Enriched with zinc, vitamin E, B6, folate and B12.DHA contributes to the maintenance of normal brain function. Zinc contributes to normal cognitive function. Vitamin E helps protect cells from oxidative stress*.
Night Powder
A stir-in powder evening drink. Natural dark-fruit flavours of Fig and pomegranate.Magnesium and vitamin B6 that support normal psychological function. Zinc supports normal cognitive function*. With glycine and Saffron extract.
A note from the founder
My nan was called Constance. She was there through every day of my childhood, from the quiet ordinary routine to the special moments. By the end, dementia had hidden her memories, masked her personality, humour, and the way she recognised the people she loved.She's the reason I realised mind-span matters as much as lifespan.This brand is her legacy. To help others age well in mind.
— Sarah, Founder. Cambridge PhD in chemistry.

Constance in her twenties
Age well in mind. For lifelong mind-span.
Be among the first to live with Constance.
Founding members get 20% off their first order, along with priority access to the first production batch and occasional founder notes on cognitive longevity.
Constance launches soon. No payment now, we will email you when it is ready to order.
By signing up you agree to receive occasional updates from Constance. We will never share your data. Unsubscribe at any time.
*DHA contributes to the maintenance of normal brain function. Vitamin E contributes to the protection of cells from oxidative stress. Zinc contributes to normal cognitive function. Magnesium and vitamin B6 contribute to normal psychological function.Constance products are food supplements, not medicines. We do not claim to prevent, treat, or cure any disease or health condition. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
Be among the first to live with Constance.
Founding members get 20% off their first order, along with priority access to the first production batch and occasional founder notes on cognitive longevity.
Constance launches soon. No payment now, we will email you when it is ready to order.
By signing up you agree to receive occasional updates from Constance. We will never share your data. Unsubscribe at any time.
*DHA contributes to the maintenance of normal brain function. Vitamin E contributes to the protection of cells from oxidative stress. Zinc contributes to normal cognitive function. Magnesium and vitamin B6 contribute to normal psychological function.Not recommended for pregnant or breastfeeding women.Constance products are food supplements, not medicines. We do not claim to prevent, treat, or cure any disease or health condition. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
A daily habit. Plant omega-3 DHA and dark fruit extracts. For your mind.
Capsules with omega-3 DHA from algal oil and patented MemophenolTM, French grape and wild blueberry extract.
Enriched with zinc, vitamin E, B6, folate and B12.DHA contributes to the maintenance of normal brain function. Zinc contributes to normal cognitive function.*
No payment now. Join the founder list for first access and 20% off when you place your first order
A daily habit. Plant omega-3 DHA, dark fruit extracts. For your mind.
Capsules with omega-3 DHA from algal oil and patented MemophenolTM, French grape and wild blueberry extract. Enriched with zinc, vitamin E, B6, folate and B12.DHA contributes to the maintenance of normal brain function. Zinc contributes to normal cognitive function.*
No payment now. Join the founder list for first access and 20% off when you place your first order
250MG OMEGA-3 DHA
Plant based from algae, not fish
225MG POLYPHENOLS
From whole grape and wild blueberry
+5 MIND-SUPPORTING NUTRIENTS
Zinc, vitamin E, B6, folate, B12
The dietary gap.
Omega-3 DHA, found in oily fish, is widely recognised to support the mind. DHA contributes to the maintenance of normal brain function.*UK guidance is one portion of oily fish a week. A portion is 140g. On average, adults manage around 56g.Constance Mind was created to help bridge that gap with a daily habit, so it's one less thing to think about.

Prized polyphenols.
Polyphenols are the compounds plants make in their skins, leaves and seeds. They’re the reason olive oil, green tea and dark chocolate have the reputations they do.In a blueberry, they’re what makes the skin dark. In a grape they sit in three places, and the richest of them is the seed. Which is the part most of us never eat, because the grapes we most often buy in the UK have been cultivated to be seedless.Memophenol is made from the whole grape, including the seeds. A patented, clinically studied extract of French grape and wild blueberry, made in Bordeaux, formulated as a pair to be absorbed together. 300mg per serving, and the same in every capsule.
Nothing added for the sake of it.
Omega-3 DHA at 250mg per serving, from algae rather than fish. DHA contributes to the maintenance of normal brain function.*Memophenol at 300mg per serving, 100mg in each capsule.Zinc at 3mg, 30% of your daily reference intake, as gentle bisglycinate. Zinc contributes to normal cognitive function.*Vitamin E at 12mg, 100% of your daily reference intake. It sits alongside the omega-3 DHA, where it protects it from oxidation. Vitamin E contributes to the protection of cells from oxidative stress.*Vitamin B6, folate and vitamin B12, each at 100% of your daily reference intake, and each in the form the body can use directly. They contribute to normal psychological function.*


Nothing added for the sake of it.
Omega-3 DHA at 250mg per serving, from algae rather than fish. DHA contributes to the maintenance of normal brain function.*Memophenol at 300mg per serving, 100mg in each capsule.Zinc at 3mg, 30% of your daily reference intake, as gentle bisglycinate. Zinc contributes to normal cognitive function.*Vitamin E at 12mg, 100% of your daily reference intake. It sits alongside the omega-3 DHA, where it protects it from oxidation. Vitamin E contributes to the protection of cells from oxidative stress.*Vitamin B6, folate and vitamin B12, each at 100% of your daily reference intake, and each in the form the body can use directly. They contribute to normal psychological function.*

An easy daily habit.
Take three capsules each morning with food.There’s nothing to measure or mix, so once you’re in the habit it becomes easy to maintain.

An easy daily habit.
Take three capsules each morning with food.There’s nothing to measure or mix, so once you’re in the habit it becomes easy to maintain.
Constance was real.
This brand is named after my nan, Constance.
She's the reason I realised mind-span matters as much as lifespan.
— Sarah, Founder. Cambridge PhD in chemistry.

Constance in her twenties
Age well in mind. For lifelong mind-span.
Reserve yours and become a founding member.
Founding members get 20% off their first order, along with priority access to the first production batch and occasional founder notes on cognitive longevity.
Mind Capsules are expected to retail at £45 for a 30-day supply. 20% off for founding members.
Constance launches soon. No payment now, we will email you when it is ready to order.
By signing up you agree to receive occasional updates from Constance. We will never share your data. Unsubscribe at any time.
*DHA contributes to the maintenance of normal brain function. This authorised claim is supported by a minimum of 250mg DHA per daily serving. Vitamin E contributes to the protection of cells from oxidative stress.Not recommended for pregnant or breastfeeding women.Constance products are food supplements, not medicines. We do not claim to prevent, treat, or cure any disease or health condition. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
An evening ritual. Nutrient-rich, dark-fruit notes. For your mind.
A deep, dark-fruit stir-in powder drink. Fig and pomegranate flavour.
Enriched with magnesium, vitamin B6, zinc, glycine and Saffr’Inside saffron extractMagnesium and vitamin B6 support normal psychological function. Zinc supports normal cognitive function.*
No payment now. Join the founder list for first access and 20% off when you place your first order
An evening ritual. Nutrient-rich, dark-fruit notes. For your mind.
A deep, dark-fruit stir-in powder drink. Fig and pomegranate flavour. Enriched with magnesium, vitamin B6, zinc, glycine and Saffr’Inside saffron extractMagnesium and vitamin B6 support normal psychological function. Zinc supports normal cognitive function.*
No payment now. Join the founder list for first access and 20% off when you place your first order
Natural dark fruit flavours
Fig & pomegranate.
Warm evening wind-down
A pre-bedtime ritual.
Glycine & saffron extract.
Mind-supporting nutrients
Magnesium, Zinc, Vitamin B6.
Dark fruit at dusk.
Mediterranean flavours of fig and pomegranate, deep and naturally sweet. For the hours before bed.

Dark fruit at dusk.
Mediterranean flavours of fig and pomegranate, deep and naturally sweet. For the hours before bed.


Minerals and nutrients for the mind.
Magnesium, zinc and vitamin B6 are readily found in the pumpkin seeds, almonds, pistachios and tahini of the Mediterranean diet.Constance Night includes magnesium at 187.5mg, 50% of your daily reference intake, as gentle glycinate. With vitamin B6 and zinc at 100% of daily reference intakes. Magnesium and vitamin B6 support normal psychological function. Zinc supports normal cognitive function.*With Glycine at 3g, the simplest of the amino acids and naturally a little sweet. And Safr’Inside at 30mg. A patented saffron extract from hand-picked stigmas, tested on every batch for authenticity.

Minerals and nutrients for the mind.
Magnesium, zinc and vitamin B6 are readily found in the pumpkin seeds, almonds, pistachios and tahini of the Mediterranean diet.Constance Night includes magnesium at 187.5mg, 50% of your daily reference intake, as gentle glycinate. With vitamin B6 and zinc at 100% of daily reference intakes. Magnesium and vitamin B6 support normal psychological function. Zinc supports normal cognitive function.*With Glycine at 3g, the simplest of the amino acids and naturally a little sweet. And Safr’Inside at 30mg. A patented saffron extract from hand-picked stigmas, tested on every batch for authenticity.
Wind down before bed.
One scoop dissolves into warm or cool water.Deep purple, layered and balanced rather than sugary.
Sweet rounded fig against the tartness of pomegranate.

Wind down before bed.
One scoop dissolves into warm or cool water. The perfect wind down.

Constance was real.
This brand is named after my nan, Constance.
She's the reason I realised mind-span matters as much as lifespan.
— Sarah, Founder. Cambridge PhD in chemistry.

Constance in her twenties
Age well in mind. For lifelong mind-span.
Reserve yours and become a founding member.
Founding members get 20% off their first order, along with priority access to the first production batch and occasional founder notes on cognitive longevity.
Night stir-in powder is expected to retail at £45 for a 30-day supply. 20% off for founding members.
Constance launches soon. No payment now, we will email you when it is ready to order.
By signing up you agree to receive occasional updates from Constance. We will never share your data. Unsubscribe at any time.
*Zinc contributes to normal cognitive function. Magnesium and vitamin B6 contribute to normal psychological function.Not recommended for pregnant or breastfeeding women.Constance products are food supplements, not medicines. We do not claim to prevent, treat, or cure any disease or health condition. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
The science of cognitive longevity.
We look after our bodies to live a long life. Most of us don’t think about our minds in the same way.This page sets out the research behind cognitive longevity, and the idea that how the mind ages can be shaped by what we do.
The science of cognitive longevity.
We look after our bodies to live a long life. Most of us don’t think about looking after our mind.This page sets out the science, and what we can do to shape how the mind ages.
Lifespan, healthspan, and mind-span.
Lifespan is how long you live. Healthspan is how many of those years you spend in good health. Mind-span is the one we think about least, because it’s the hardest to see. It’s how long the mind stays sharp as the years add up.A sharp mind means thinking quickly, finding the word in the moment, the name still there, holding the thread of a thought, knowing why you walked into the room. A mind that still feels like yours.We’re all living longer. There’s no guarantee our minds will keep pace.
How the mind ages.
Some cognitive change is a normal part of getting older. Names take a moment longer, focus wanders more easily. It is ordinary, and it begins earlier than most people expect. One large study measured it from the mid-forties1.But the way the mind ages is not fixed. In a two-year programme of diet, exercise and mental activity, older adults improved their cognition more than those who carried on as usual2, a finding more recent trials have continued to test3.Everyday habits shape how the mind holds up, and midlife is when it starts to really matter.
45 years
the age at which cognitive decline becomes measurable
25%
greater improvement in cognition shown in a 2 year program of diet, exercise & mental activity
7 hours
sleep associated with healthy cognition in published studies

Diet and the ageing mind.
The Mediterranean diet is among the most frequently studied for its links to the ageing brain. Its pattern includes olive oil, oily fish, nuts, seeds and dark fruit, eaten regularly rather than occasionally. In long-term observational research, regular olive oil users showed slower cognitive decline than those who rarely used it4.Flavonoids, a group of polyphenols found in dark berries, have been studied separately. In a long-running cohort of older women, higher long-term intake of berries was associated with slower rates of cognitive decline5. A larger study of nearly 80,000 men and women found a similar pattern for total flavonoid intake6.These are observational findings about diet, not trials of any product.

Diet and the ageing mind.
The Mediterranean diet is among the most frequently studied for its links to the ageing brain. Its pattern includes olive oil, oily fish, nuts, seeds and dark fruit, eaten regularly rather than occasionally. In long-term observational research, regular olive oil users showed slower cognitive decline than those who rarely used it4.Flavonoids, a group of polyphenols found in dark berries, have been studied separately. In a long-running cohort of older women, higher long-term intake of berries was associated with slower rates of cognitive decline5. A larger study of nearly 80,000 men and women found a similar pattern for total flavonoid intake6.These are observational findings about diet, not trials of any product.
The role of deep sleep.
The mind does some of its most important work while you sleep. During deep sleep, the brain consolidates the day’s memories, which helps everyday recall and focus. Research also suggests it is when the brain clears metabolic waste accumulated during the day.Deep sleep becomes harder to reach as we get older, and around seven hours is the amount most consistently associated with healthy cognition in middle and older age 7. Protecting it, night after night, is one of the quieter ways of shaping your mind in twenty years’ time.

The role of deep sleep.
The mind does some of its most important work while you sleep. During deep sleep, the brain consolidates the day’s memories, which helps everyday recall and focus. Research also suggests it is when the brain clears metabolic waste accumulated during the day.Deep sleep becomes harder to reach as we get older, and around seven hours is the amount most consistently associated with healthy cognition in middle and older age 5. Protecting it, night after night, is one of the quieter ways of shaping your mind in twenty years’ time.

The good news.
No single habit can stop cognitive ageing. But the sum of ordinary choices, repeated through midlife, can change its pace. It’s what you eat, how you move, how you sleep, how you keep your mind active, and more. Whilst there’s much more science has to learn, it’s clear that the mind you have in twenty years is being shaped by the decades in between.That is reason for us all to act.
The good news.
No single habit can stop cognitive ageing. But the sum of ordinary choices, repeated through midlife, can change its pace. It’s what you eat, how you move, how you sleep, how you keep your mind active, and more.Whilst there’s much more science has to learn, it’s clear that the mind you have in twenty years is being shaped by the decades in between.That is reason for us all to act.
References
1. Whitehall II cohort. Singh-Manoux et al. BMJ, 2012.
2. FINGER. Ngandu et al. The Lancet, 2015.
3. US POINTER. Baker et al. 2025.
4. Three-City Study. Berr et al. 2009. Observational.
5. Nurses' Health Study. Devore et al. Annals of Neurology, 2012. Observational.
6. Nurses' Health Study and Health Professionals Follow-Up Study. Yeh et al. Neurology, 2021. Observational.
7. Sleep and cognition. Li et al. Nature Aging, 2022. UK Biobank.
This page describes published, peer-reviewed research, not trials of Constance products.Constance products are food supplements, not medicines. We do not claim to prevent, treat or cure any disease or health condition. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.